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KMID : 1011420090140030095
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Journal of Korean Ophthalmic Optics Society
2009 Volume.14 No. 3 p.95 ~ p.102
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Antimicrobial Activity of Allyl Derivate in Multi-purpose Solution as Natural Preservative
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Lee Ji-Young
Suh Seung-Kyo
Sung Duk-Yong
Youk Do-Jin
Lee Koon-Ja
Chung Jae-Yong
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Abstract
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Purpose: The purpose of this study is to investigate antimicrobial activity of ally derivative of garlic against eye diseases, and to get basic data for an application development of the derivative, as a natural preservative, to multi-purpose solution (MPS).
Methods: Antimicrobial activity of allyl derivative of garlic, diallyl sulfide (DAS), against Pseudomonas aeruginosa (P. aeruginosa) and Staphyloccus aereus (S. aereus) was determined. After DAS treatment in MPS of no microbial activity, its growth inhibition effect to bacteria was also determined.
Results: DAS concentrations of IC50 against P. aeruginosa and S. aereus were found when both bacteria were treated with DAS concentration of 0.25% and 0.64%, respectively. At MPS test, a product from Company A did not show any effects against both bacteria, but one from Company B showed antimicrobial activity against both bacteria. Antimicrobial activity test of the product from Company B in MPS did not showed any significant difference on both gram-negative and gram-positive bacteria. For a trial application of antimicrobial activity of DAS as a natural preservative, DAS was added to MPS of Company A which did not show any antimicrobial activity at treated concentration. Addition of DAS into MPS of Company A resulted in antimicrobial activity of DAS, which suggested a possible application of DAS as a germicide for contact lenses.
Conclusions: This study showed allyl derivative of garlic has antimicrobial activity against both P. aeruginosa and against S. aereus, but more effects on P. aeruginosa. The result suggests that allyl derivative derived from garlic can be developed to a preservative of MPS as a natural substance.
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KEYWORD
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Diallyl sulfide, DAS, Garlic, multi-purpose solution, MPS, Antimicrobial activity
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